BAK is a pro-apoptotic mitochondrial protein that can drive selective cancer cell death, particularly in tumors with BAK expression, such as certain subsets of non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), breast cancer, colon cancer, lymphoma, multiple myeloma, osteosarcoma, and pancreatic cancer. Our lead molecule, 7PB-100, activates BAK to selectively kill cancer cells, halt tumor growth, and overcome treatment resistance while causing minimal harm to healthy tissue.